Why plaque forms in arteries and how to stop it
Abstract 9360: Increasing Mass Transfer Flux of Low-Density Lipoproteins-Cholesterol or Apolipoprotein B at the Endothelium of Atherogenic Sites as a Primary Target of Atherosclerotic Cardiovascular Disease
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When bad cholesterol (LDL-c) and its carrier (Apo B) move too fast into artery walls due to high blood pressure, fast heartbeat, or stiff heart, they build up and cause plaque. A new formula using these five signs can predict heart disease risk.
Surprising Findings
The study proposes that the *movement* of LDL-c/Apo B into artery walls (flux) is more important than just their concentration in blood.
For decades, doctors have focused on lowering total LDL-c levels. This suggests the *rate* of entry into the artery wall—driven by biomechanics like blood flow and stiffness—might be the real culprit.
Practical Takeaways
If you have high blood pressure, fast resting heart rate, or known arterial stiffness, ask your doctor about checking Apo B levels—not just LDL-c.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When bad cholesterol (LDL-c) and its carrier (Apo B) move too fast into artery walls due to high blood pressure, fast heartbeat, or stiff heart, they build up and cause plaque. A new formula using these five signs can predict heart disease risk.
Surprising Findings
The study proposes that the *movement* of LDL-c/Apo B into artery walls (flux) is more important than just their concentration in blood.
For decades, doctors have focused on lowering total LDL-c levels. This suggests the *rate* of entry into the artery wall—driven by biomechanics like blood flow and stiffness—might be the real culprit.
Practical Takeaways
If you have high blood pressure, fast resting heart rate, or known arterial stiffness, ask your doctor about checking Apo B levels—not just LDL-c.
Publication
Journal
Circulation
Year
2021
Authors
Xingyan Wang
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Claims (6)
A new formula that combines cholesterol levels, blood pressure, heart rate, and heart stiffness gives risk scores for heart disease that match up with the official guidelines doctors already use.
High cholesterol, high blood pressure, fast heartbeat, and stiff heart chambers all seem to work together to push more bad cholesterol into artery walls where plaques form.
Scientists created a new formula that uses multiple health numbers to help figure out who’s at risk for heart disease and how to stop it — by focusing on how fast bad cholesterol moves into artery walls.
This formula was tested on data from nearly 100,000 people and might help prevent heart disease and save a lot of money — but it hasn’t been proven yet.
When LDL cholesterol or Apo B particles move faster from blood into artery walls at certain spots, they build up and contribute to heart disease — this movement might be more important than just having high levels in the blood.