The Study
Safety, efficacy, and on-treatment circulating tumor DNA (ctDNA) changes from a phase 1 study of RMC-6236, a RAS(ON) multi-selective, tri-complex inhibitor, in patients with RAS mutant pancreatic ductal adenocarcinoma (PDAC).
This study watched what happened when 127 people took a new medicine, but it didn't compare them to others who didn't take it or use chance to decide who got it. So we can say what happened to these people, but we can't say the medicine caused the improvements — it might just be luck or other factors.
Analysis score
Maximum 90 for a randomized controlled trial.
Where the score came from
A new pill called RMC-6236 was tested in patients with advanced pancreatic cancer who had already tried other treatments.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 538 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1This is promising because most patients with this cancer survive only 6–7 months with standard treatment, but here, half lived over 14 months and many had cancer DNA vanish from blood.
- 2In 56 patients with KRAS G12X mutation, 95% had over half their cancer DNA in blood disappear, and half had all detectable cancer DNA vanish.
- 3The pill helped 29% of patients' tumors shrink.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Journal of Clinical Oncology
Year
2025
Authors
I. Garrido-Laguna, B. Wolpin, Wungki Park, Nilofer S. Azad, A. Spira, Alexander N Starodub, D. Sommerhalder, Salman R. Punekar, B. Herzberg, M. Barve, Meredith S. Pelster, Jennifer B. Valerin, J. R. Hecht, Rashmi Vora, A. Hegde, Clay Gustafson, Lin Tao, S. Kar, Kevin K. Lin, D. Hong
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Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.