Does Blocking Growth Hormone Improve Insulin Sensitivity During Fasting in Obese People?
Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Researchers gave obese men a drug (pegvisomant) to block growth hormone while they fasted for 3 days. They compared this to normal fasting and a regular fed state. The drug helped their bodies respond better to insulin and produce less glucose.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
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Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Researchers gave obese men a drug (pegvisomant) to block growth hormone while they fasted for 3 days. They compared this to normal fasting and a regular fed state. The drug helped their bodies respond better to insulin and produce less glucose.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 541 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Pedersen MH, Svart MV, Lebeck J, Bidlingmaier M, Stødkilde-Jørgensen H, Pedersen SB, Møller N, Jessen N, Jørgensen JOL
Related Content
Claims (5)
When men with obesity fast for 3 days while also blocking growth hormone, their bodies become better at using insulin again.
When obese men go without food for 3 days, their bodies make more growth hormone.
Growth hormone helps control how the body breaks down and uses energy from food, and it affects how well the body responds to insulin—especially in people who are obese.
When obese men fast for 3 days, blocking their growth hormone lowers the amount of sugar their bodies produce.
When obese men fast, blocking growth hormone makes insulin better at reducing fat-related molecules in their blood.