Can a new shot calm an overactive thyroid?

Original Title

OR31-08 The FcRn Inhibitor Batoclimab Rapidly Normalizes Thyroid Function and Improves Clinical Outcomes in Graves’ Disease

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Summary

This study tested a new medicine called batoclimab that removes harmful antibodies causing the thyroid to overproduce hormones in people with Graves’ disease.

Proposed Mechanism
FcRn inhibition reduces pathogenic IgG autoantibodies
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Quality Analysis
Methodology
20%
Lower QualityOverall Score
Randomized Controlled TrialMedicine

Systematic Reviews & Meta-Analyses

Max 100

Randomized Controlled Trials

Max 90

Cohort Studies

Max 72

Case-Control Studies

Max 58

Cross-Sectional Studies

Max 44

Case Reports & Case Series

Max 30

Expert Opinion & Narrative Reviews

Max 5
StrongerWeaker
Randomized Controlled Trials
Level 1b
20

20 / 90

Evidence Score

Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.

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