Can a thyroid medicine cause your body to attack itself?

Original Title

From Thyroid Therapy to Systemic Crisis: PTU-Induced c-ANCA Vasculitis Accompanied by Cold-Agglutinin Disease and Organ Failure

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Summary

A woman took a medicine for her overactive thyroid, stopped it, but then her immune system started attacking her kidneys, pancreas, and blood cells — like a friendly fire accident.

Proposed Mechanism
PTU-induced ANCA vasculitis via neutrophil priming and NET formation
Suggested
PTU-induced cold agglutinin disease via polyclonal B-cell activation
Suggested
Vasculitis-mediated pancreatitis via microvascular ischemia
Suggested

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Quality Analysis
Methodology
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Publication

Authors

Kefala-Karli P, Christou T, Georgiou E, Pavlou D, Kapouralos A, Panagi K, Chalmoukou K