Genes affect how well cholesterol medicine works
Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
No patients were found with the CC genotype despite testing 66 individuals.
Given standard genetic inheritance patterns, some CC individuals would be expected in a group of this size, especially if the C allele is present. Its complete absence is unusual and not explained in the abstract.
Practical Takeaways
Talk to your doctor about pharmacogenetic testing if you're on statins and not seeing expected cholesterol improvements.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
No patients were found with the CC genotype despite testing 66 individuals.
Given standard genetic inheritance patterns, some CC individuals would be expected in a group of this size, especially if the C allele is present. Its complete absence is unusual and not explained in the abstract.
Practical Takeaways
Talk to your doctor about pharmacogenetic testing if you're on statins and not seeing expected cholesterol improvements.
Publication
Journal
Drug metabolism and pharmacokinetics
Year
2004
Authors
Rieko Tachibana-Iimori, Y. Tabara, H. Kusuhara, K. Kohara, R. Kawamoto, J. Nakura, K. Tokunaga, I. Kondo, Y. Sugiyama, T. Miki
Related Content
Claims (4)
A type of drug that lowers cholesterol works well in lab tests, but high doses can be toxic in animals, which might slow down its use in people.
Some Japanese people with high cholesterol don't respond as well to certain cholesterol drugs if they have a specific gene variant — their cholesterol doesn't drop as much as in people without that gene.
Some Japanese people might respond differently to cholesterol-lowering statin drugs because of a specific gene variation they have — this gene might affect how well the drug works for them.
Taking cholesterol-lowering drugs like statins really does lower cholesterol in Japanese people with high cholesterol, just like it does in others.