The Study
The Effects of Curcumin Plus Piperine Co-administration on Inflammation and Oxidative Stress: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
This study looked at lots of small experiments where people took curcumin and piperine and measured things like inflammation in their blood. It found that, on average, these supplements seemed to lower some bad markers and raise some good ones. But it didn’t test if people felt better or got healthier overall — just what happened in their blood.
Analysis score
Maximum 100 for a systematic review with meta-analysis.
Where the score came from
This study looked at whether taking turmeric (curcumin) with black pepper (piperine) helps the body fight inflammation and damage from stress.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 539 / 100
Quality score
The highest quality evidence. Systematic reviews and meta-analyses that pool randomized controlled trials, giving the most reliable summary of experimental evidence.
Key takeaways
Summary
Based on the study abstract and findings.
- 1These changes are measurable in blood tests, but it's not clear yet if they make people feel better or slow down disease.
- 2People who took curcumin + piperine had higher levels of protective antioxidants (SOD, GSH) and lower levels of damage markers (MDA, TNF-α, IL-6).
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Current medicinal chemistry
Year
2024
Authors
Hossein Hosseini, Farideh Ghavidel, Arezoo Rajabian, Masoud Homayouni-Tabrizi, Muhammed Majeed, A. Sahebkar
Related Content
Claims (8)
Piperine enhances the amount of curcumin that enters the bloodstream by blocking its chemical breakdown in the intestines and liver.
Taking curcumin and piperine supplements lowers levels of the inflammatory markers TNF-α and IL-6 in the blood of adults with chronic low-grade inflammation.
Taking curcumin with piperine increases how much curcumin enters the bloodstream and leads to detectable changes in markers of oxidative stress and inflammation in humans.
Curcumin and piperine together change levels of certain biological markers related to oxidative stress and inflammation, but it is not known whether these changes affect how people feel or how their diseases progress.
Supplementing with curcumin and piperine is linked to measurable reductions in markers of oxidative stress and inflammation in people with metabolic or chronic inflammatory diseases.
Curcumin combined with piperine raises levels of superoxide dismutase and glutathione while lowering malondialdehyde, which are biomarkers of reduced oxidative stress.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.