iXAN™ (Lutein, Zeaxanthin and Curcuminoids) Enhances Retinal Antioxidant Capacity and Macular Carotenoid Deposition to Attenuate Blue-Light–Induced Phototoxicity

Lutein and zeaxanthin build up in the central part of the retina and absorb blue light, which reduces damage to light-sensitive cells.

When human retinal cells are exposed to a supplement containing lutein, zeaxanthin, and curcuminoids at concentrations up to 1000 µg/mL, more than 93% of the cells remain alive, showing that the substance is not toxic to these cells at this dose.

In rats, oral dosing with a specific formulation of lutein, zeaxanthin, and curcuminoids at 62 mg per kilogram of body weight increases lutein and zeaxanthin levels in the retina, restores activity of key antioxidant enzymes in the blood, reduces accumulation of a toxic compound in retinal cells caused by blue light, and prevents thinning of the outer nuclear layer and damage to photoreceptors.

In rats exposed to intense blue light, a specific supplement containing lutein, zeaxanthin, and curcuminoids restores levels of three key antioxidant enzymes in the blood to near-normal levels.

In human retinal cells exposed to UV light, a specific supplement formulation at 500 µg/mL reduces the buildup of a toxic compound called A2E by 24% compared to cells not treated with the supplement, and does not reduce cell survival.

In rats with retinal damage caused by blue light, taking a specific supplement containing lutein, zeaxanthin, and curcuminoids at a dose of 62 mg per kilogram of body weight increases the levels of these compounds in the blood and retina, with measurable concentrations detected in retinal tissue.