What does PCSK9 do and how can we stop it?
Regulation of PCSK9 Expression and Function: Mechanisms and Therapeutic Implications
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
PCSK9 is a protein that destroys good receptors in your body that help clean bad cholesterol from your blood and help your immune system fight cancer. When we block PCSK9, more of these helpful receptors stay active.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 51 / 5
Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
PCSK9 is a protein that destroys good receptors in your body that help clean bad cholesterol from your blood and help your immune system fight cancer. When we block PCSK9, more of these helpful receptors stay active.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 51 / 5
Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Publication
Authors
Xia XD, Peng ZS, Gu HM, Wang M, Wang GQ, Zhang DW
Related Content
Claims (6)
A protein called PCSK9 helps break down the liver's 'LDL cholesterol cleaners,' so more bad cholesterol stays in your blood, raising heart disease risk. People with certain PCSK9 gene changes either have very high or very low cholesterol levels.
A type of medicine (like evolocumab or alirocumab) blocks a protein in your body called PCSK9, which helps your liver remove bad cholesterol from your blood—cutting it by about half.
Blocking a protein called PCSK9 helps the immune system better recognize and attack cancer cells in mice, slowing tumor growth — and it works in a way that's not related to cholesterol.
Some cholesterol-lowering drugs called PCSK9 inhibitors can lower a specific type of blood fat linked to heart disease, and that might help protect people with high levels, but scientists aren't sure exactly how it works yet.
A protein called PCSK9 causes the liver to break down fewer 'bad' cholesterol carriers, which means more of it stays in your blood.