Can blocking a protein called Ninj1 stop artery clogging?
Ninjurin-1 drives atherosclerosis progression via NF-κB/CXCL-8 activation in endothelial cells
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A protein called Ninj1 makes blood vessel lining cells get inflamed and die when exposed to bad cholesterol. This helps clogs form in arteries. When scientists blocked Ninj1, the cells stayed healthy and fewer clogs formed.
Systematic Reviews & Meta-Analyses
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Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
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Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A protein called Ninj1 makes blood vessel lining cells get inflamed and die when exposed to bad cholesterol. This helps clogs form in arteries. When scientists blocked Ninj1, the cells stayed healthy and fewer clogs formed.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 514 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
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Claims (6)
The buildup of fats and plaques in artery walls requires prior inflammation of the inner lining of blood vessels.
In mice genetically predisposed to atherosclerosis and fed a high-fat diet, a specific peptide called mPN12 that blocks Ninjurin-1 reduces the size of fatty plaques in arteries by about 42.5% and lowers lipid buildup inside those plaques by 20%, without changing the amount of collagen present.
In mice genetically predisposed to atherosclerosis, a protein called Ninjurin-1 is found at higher levels in the lining of blood vessels when they develop fatty plaques, especially when the mice are fed a high-fat diet. This suggests the protein may be specifically involved in the inflammatory response within these vessel walls.
In mice genetically predisposed to arterial inflammation, a specific peptide called mPN12 reduces the production of a signaling molecule called Cxcl2 in the aorta when it blocks the Ninjurin-1 protein.
When Ninjurin-1 is turned off in human blood vessel cells exposed to a harmful form of cholesterol, cell death decreases by 72%, and the cells regain their ability to multiply and move closer to normal levels.