How your brain knows when you're full
TRPC1/5-CaV3 Complex Mediates Leptin-Induced Excitability in Hypothalamic Neurons
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When you eat, a hormone called leptin tells your brain to stop eating. This study found that leptin works like a two-step switch: first, it opens a door (TRPC channel) that lets in sodium and calcium, which slightly warms up the neuron. Then, that warmth turns on a second door (T-type calcium...
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Researchers compare people who have a condition (cases) with similar people who do not (controls), looking back in time for differences in exposure. Useful but more prone to bias.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When you eat, a hormone called leptin tells your brain to stop eating. This study found that leptin works like a two-step switch: first, it opens a door (TRPC channel) that lets in sodium and calcium, which slightly warms up the neuron. Then, that warmth turns on a second door (T-type calcium...
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 512 / 58
Evidence Score
Researchers compare people who have a condition (cases) with similar people who do not (controls), looking back in time for differences in exposure. Useful but more prone to bias.
Publication
Authors
Perissinotti PP, Martínez-Hernández E, Piedras-Rentería ES
Related Content
Claims (6)
Cav3.1 channels control the entry of calcium ions into specific brain cells called POMC neurons, which are involved in signaling fullness after eating.
In mouse brain cells called POMC neurons, leptin does not directly change how T-type calcium channels open or close; instead, it affects these channels indirectly by causing the cell membrane to depolarize through activation of TRPC channels.
In mouse brain cells called POMC neurons, blocking TRPC or T-type calcium channels stops leptin from making the cells more active, including preventing the decrease in the minimum current needed to trigger firing and the increase in firing rate.
In mouse brain cells called POMC neurons, the hormone leptin triggers a sequence of ion channel activations that increases calcium influx and makes the cells fire electrical signals more readily.
In mouse hypothalamic neurons, TRPC1 and TRPC5 ion channels bind directly to CaV3.1 and CaV3.2 T-type calcium channels to form a stable protein complex.