The Study
Myofibril and Mitochondrial Area Changes in Type I and II Fibers Following 10 Weeks of Resistance Training in Previously Untrained Men
This study is like taking before-and-after pictures of 15 men who started weightlifting. It shows what changed in their muscles after 10 weeks, but it can't prove the weightlifting caused all the changes because there was no comparison group that didn't exercise.
Analysis score
Maximum 72 for a cohort study.
Where the score came from
Lifting weights makes muscles bigger and stronger by growing the parts inside muscle cells in different ways.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 531 / 100
Quality score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes, it shows how muscles adapt structurally to training, which is important for understanding strength gains.
- 2Muscle fibers grew bigger, the contractile parts grew evenly, energy parts grew faster, and a scan could track these changes.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Frontiers in Physiology
Year
2021
Authors
Bradley A Ruple, Joshua S Godwin, Paulo H. C. Mesquita, Shelby C. Osburn, C. Sexton, Morgan A Smith, Jeremy C. Ogletree, Michael D. Goodlett, Joseph L. Edison, A. Ferrando, A. Frugé, A. Kavazis, Kaelin C. Young, M. Roberts
Related Content
Claims (6)
When scientists measure changes in muscle cells after strength training using two different methods, the results don't match up well - so they should be looked at separately rather than compared directly.
When young guys who haven't lifted weights before do strength training for 10 weeks, their muscle fibers grow in a way that makes them stronger, not just bigger with extra fluid. It's like building real muscle instead of just puffing it up.
When young guys who don't exercise start lifting weights for 10 weeks, the energy-producing parts inside their muscles grow faster than the muscles themselves.
When untrained young men do strength training, a special scan called pQCT can show changes in muscle density that match changes in muscle fiber size, suggesting this scan might help track muscle growth without surgery.
In young men who don't exercise, slow-twitch muscle fibers have more energy-producing parts than fast-twitch fibers to start with, and even after 10 weeks of weight training—which boosts these parts overall—the slow-twitch ones still keep their lead.
In young men who don't exercise, fast-twitch muscle fibers are more tightly packed with muscle-building parts than slow-twitch fibers. When they start lifting weights, this difference stays the same, but all muscle fibers get bigger.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.