How a low-carb diet helped kids lose weight and feel better

Original Title

Low-Carbohydrate (Ketogenic) Diet in Children with Obesity: Part 2—Hormonal Effects of the Ketogenic Diet

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Summary

Kids who ate mostly meat, eggs, and veggies instead of bread and sugar lost weight and their bodies made less of the hormone that stores fat (insulin), less stress hormone (cortisol), and more of the hormone that helps burn fat (adiponectin). Girls with irregular periods all got their periods back.

Proposed Mechanism
Ketogenic Diet Reduces Insulin Secretion and Improves Insulin Sensitivity
Supported by evidence
Ketogenic Diet Improves PCOS via Insulin-Mediated Reduction in Androgen Production
Supported by evidence
Ketogenic Diet Increases Adiponectin Secretion via Ketone Body Signaling and Anti-Inflammatory Effects
Supported by evidence
Ketogenic Diet Lowers Cortisol via Reduction in Visceral Adiposity and HPA Axis Modulation
Supported by evidence
Ketogenic Diet Alters Thyroid Hormone Metabolism via Peripheral Deiodinase Modulation
Suggested

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Quality Analysis
Methodology
47%
Moderate QualityOverall Score
Cohort StudyMedicine

Systematic Reviews & Meta-Analyses

Max 100

Randomized Controlled Trials

Max 90

Cohort Studies

Max 72

Case-Control Studies

Max 58

Cross-Sectional Studies

Max 44

Case Reports & Case Series

Max 30

Expert Opinion & Narrative Reviews

Max 5
StrongerWeaker
Cohort Studies
Level 2
47

47 / 72

Evidence Score

Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.

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