Why 'forever chemicals' are bad for your body

Original Title

Toxicological Effects and Health Impacts of Per- and Polyfluoroalkyl Substances (PFAS) in Humans

Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms

Summary

These man-made chemicals don't break down and build up in your blood. They can mess with your hormones, weaken your immune system, hurt your liver and kidneys, and raise your cancer risk.

Proposed Mechanism
PFAS disruption of thyroid hormone transport
Verified
PFAS inhibition of thyroid hormone synthesis via NIS suppression
Verified
PFAS activation of PPARα leading to hepatic lipid accumulation
Verified
PFAS suppression of NUDT7 leading to impaired fatty acid oxidation
Verified
PFAS disruption of bile acid homeostasis via HNF4α and Cyp7A1 suppression
Verified
PFAS inhibition of hepatic uptake transporters (NTCP/OATPs)
Verified
PFAS activation of CAR/PXR leading to sustained xenobiotic metabolism dysregulation
Verified
PFAS suppression of RAG1/RAG2 impairing B-cell antibody diversity
Verified
PFAS inhibition of steroidogenic enzymes in Leydig cells
Verified
PFAS disruption of ovarian steroidogenesis via StAR and enzyme inhibition
Verified
PFAS induction of oxidative stress in spermatozoa
Verified
PFAS activation of GPER mediating non-genomic estrogenic signaling
Verified
PFAS-induced platelet activation via GPIbα binding
Verified
PFAS suppression of kisspeptin signaling impairing GnRH release
Supported by evidence
PFAS-induced epigenetic alterations promoting carcinogenesis
Supported by evidence
PFAS-mediated immunosuppression via JAK-STAT and Th17 pathway disruption
Verified

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Quality Analysis
Methodology
2%
Lower QualityOverall Score
Narrative ReviewMedicine

Systematic Reviews & Meta-Analyses

Max 100

Randomized Controlled Trials

Max 90

Cohort Studies

Max 72

Case-Control Studies

Max 58

Cross-Sectional Studies

Max 44

Case Reports & Case Series

Max 30

Expert Opinion & Narrative Reviews

Max 5
StrongerWeaker
Expert Opinion & Narrative Reviews
Level 5
2

2 / 5

Evidence Score

Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.

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