The Study
Bioactive substances from Red ginger rhizome (Zingiber officinale Roscoe var. sunti Val) as Anti-atherosclerotic agent: Inhibition of Lipoxygenase in arachidonic acid metabolism
This study tested a ginger extract in a petri dish with some immune cells, and saw that it stopped certain chemicals from being made. But it didn't test this in people or animals, so we can't say it helps humans at all.
Analysis score
Maximum 58 for a case-control study.
Where the score came from
Scientists tested a special part of red ginger on immune cells in a dish to see if it can calm down inflammation that causes clogged arteries.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 546 / 100
Quality score
Researchers compare people who have a condition (cases) with similar people who do not (controls), looking back in time for differences in exposure. Useful but more prone to bias.
Key takeaways
Summary
Based on the study abstract and findings.
- 1These numbers show strong effects in a lab dish, but we don't know yet if eating ginger does the same in people.
- 2The ginger extract stopped a key inflammation enzyme at 36.4 µg/ml and reduced bad fats in cells at 45.97 µg/ml.
- 3It also lowered two inflammation signals (TNF-α and IL-6).
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Research Journal of Pharmacy and Technology
Year
2024
Authors
Siti Wakhidatun Suciyati, S. Sukrasno, Neng Fisheri Kurniati, I. K. Adnyana
Related Content
Claims (6)
A specific compound from red ginger decreases the production of TNF-α and IL-6 cytokines in human macrophage cells grown in laboratory cultures.
Fraction F6 from red ginger root contains 194.99 ± 1.43 milligrams per gram of 6-gingerol, as well as zingerone, 6-paradol, and 6-shogaol. These compounds have been linked to anti-inflammatory effects in prior research.
Fraction F6 from red ginger extract reduces lipoxygenase enzyme activity, lowers TNF-α and IL-6 cytokine levels, and decreases lipid peroxidation in macrophage cells under laboratory conditions.
A specific compound from red ginger, called fraction F6, reduces lipid peroxidation in macrophage cells under laboratory conditions at a concentration of 45.97 µg/ml.
Red ginger extract fraction F6 reduces inflammation in artery plaques by blocking the lipoxygenase pathway involved in arachidonic acid metabolism.
Compounds in ginger block two enzymes involved in inflammation, leading to lower levels of prostaglandins and leukotrienes.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.