The Study
A clinical evaluation of liposomal (Lipomac™) versus nonliposomal vitamin C: A randomized, open-label, cross-over trial in healthy subjects
This study showed that one kind of vitamin C pill gets into the blood more than another kind — like seeing which juice gets absorbed faster. But it didn’t test if that makes people healthier, so we can’t say it’s better for you — just that it shows up more in blood tests.
Analysis score
Maximum 90 for a randomized controlled trial.
Where the score came from
Scientists tested two kinds of vitamin C pills: one wrapped in tiny fat bubbles (liposomal), and one regular. They measured how much got into the blood.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 544 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — the fat-bubble version put more than twice as much vitamin C into the bloodstream, which might mean it works better.
- 2The fat-bubble vitamin C reached 16,462 ng/mL in blood and stayed in the body longer (AUC: 122,809), while the regular one only reached 6,950 ng/mL (AUC: 60,506).
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Natural Resources for Human Health
Year
2026
Authors
Sravani Thimmannagari, Shivaprasad Hn, Arnab Chatterjee, Madhu Krishnamani, Gaurav Soni, D. Manohar
Related Content
Claims (4)
The chemical structure of nutrients in supplements determines how much of the nutrient the body can absorb and use.
When taken orally, liposomal vitamin C (Lipomac™) reaches 2.36 times higher levels in the blood than regular vitamin C, based on measurements of peak concentration and total exposure over time.
Vitamin C delivered in liposomes results in 2.36 times higher levels in the bloodstream compared to standard vitamin C supplements in healthy adults.
When healthy adults take liposomal vitamin C, the highest level in the blood occurs 4 hours after ingestion. Nonliposomal vitamin C reaches peak blood levels faster.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.