The Study
EFFECT OF AGING AND OBESITY RELATED TESTOSTERONE DECLINE ON SERUM ADIPONECTIN LEVELS OF HEALTHY MALES
This study looked at a group of men once and found that older and heavier men tended to have less testosterone and more adiponectin. But it didn't watch them over time, so we can't say if being heavier made testosterone drop, or if low testosterone made people gain weight — it just shows they often happen together.
Analysis score
Maximum 44 for a cross-sectional study.
Where the score came from
As men get older or gain weight, their testosterone (a key male hormone) goes down, while adiponectin (a fat-related hormone) goes up — and they seem to be linked.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 543 / 100
Quality score
Snapshots of a population at a single point in time, or descriptions of small groups. Can identify correlations and prevalence, but cannot determine cause and effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — lower testosterone and higher adiponectin in older, obese men may increase risk for metabolic problems like diabetes or heart disease.
- 2Testosterone dropped by about 54% from young non-obese to elderly obese men.
- 3Adiponectin was highest in elderly obese men.
- 4Testosterone and adiponectin always moved in opposite directions.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Pakistan Journal of Physiology
Year
2024
Authors
Hamid Hassan, Muniza Saeed, Saadat Ali Khan, M. Murtaza, M. Nadeem
Related Content
Claims (6)
Healthy adult men between 20 and 60 years old who are obese have lower testosterone levels in their blood than men who are not obese, and testosterone levels decrease further as men get older, with the lowest levels found in older men who are obese.
In healthy adult men, older age and obesity are both linked to higher levels of adiponectin in the blood, and the highest levels occur in men who are both older and obese.
In healthy adult men, higher levels of testosterone are consistently linked to lower levels of adiponectin, and this relationship is stronger in older men and in men with obesity.
In healthy adult men, older men show a stronger inverse relationship between testosterone and adiponectin levels than younger men.
In healthy adult men, having both aging and obesity is linked to lower testosterone and higher adiponectin levels than having either condition by itself.
Between 1972 and 2019, the average testosterone level in men dropped by 54%, which equals more than a 1% decrease each year.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.