Can sound waves clean brain gunk and help memory?
Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Healthy mice improved memory just as much as Alzheimer’s mice—despite having no disease pathology.
Everyone assumed ultrasound only helped diseased brains; this shows it may enhance normal brain function, which contradicts the assumption that it’s purely therapeutic.
Practical Takeaways
Stay informed about clinical trials like NCT04118764—this tech may become available for early Alzheimer’s patients within 5–7 years.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Healthy mice improved memory just as much as Alzheimer’s mice—despite having no disease pathology.
Everyone assumed ultrasound only helped diseased brains; this shows it may enhance normal brain function, which contradicts the assumption that it’s purely therapeutic.
Practical Takeaways
Stay informed about clinical trials like NCT04118764—this tech may become available for early Alzheimer’s patients within 5–7 years.
Publication
Journal
Theranostics
Year
2023
Authors
M. Karakatsani, R. Ji, Maria F. Murillo, Tara Kugelman, Nancy Kwon, Yeh-Hsing Lao, Keyu Liu, A. Pouliopoulos, Lawrence S. Honig, K. Duff, E. Konofagou
Related Content
Claims (6)
Scientists found that using a special sound wave treatment on mice with Alzheimer’s-like brain changes reduced two key signs of the disease—tau protein buildup and tangled nerve cell branches—by nearly a third and half, respectively, after four treatments.
Scientists found that mice given a special sound treatment with tiny bubbles in their brains remembered better where they were in a water maze, and this worked for both regular mice and genetically modified ones.
Scientists use sound waves and tiny bubbles to temporarily open a gate in the brain’s protective barrier, letting the brain’s own cleanup crew remove harmful gunk called amyloid-beta plaques.
Scientists used a special sound wave treatment on mice with Alzheimer’s-like brain changes, and after four weekly sessions, they saw fewer and smaller clumps of harmful protein in the memory area of the brain—but the loose, floating version of that protein didn’t change much.
A doctor used a special sound wave treatment with tiny bubbles in one person with early Alzheimer’s, and for a few weeks, the brain’s Alzheimer’s protein markers went down a little—but then they went up even higher by three months.