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The Study

Comparative Efficacy and Pharmacokinetic Parameters of Micronized Creatine Monohydrate (KleanCREATINE™) in Active Men: A Randomized, Controlled Clinical Study

In simple terms

This study gave two different kinds of creatine to two groups of guys who lift weights and saw which one helped them get stronger and leaner. Because they didn't know which one they got, we can say the better results probably happened because of the supplement, not luck.

75%

Analysis score

75/ 90

Maximum 90 for a randomized controlled trial.

Where the score came from

Reporting40
Methodology81
Publication100
Statistical77
Study type (basis of the score)
Randomized Controlled Trial
Level 1b - Individual RCT
What’s the bottom line?

This study tested a new kind of creatine powder called KleanCREATINE™ and found it gets into your blood faster and better than regular creatine.

Where does this study sit?

Reviews of RCTs (Meta-analyses)

Max 100

Randomized Trials

Max 90

Reviews of Cohort Studies

Max 85

Cohort Studies

Max 72

Reviews of Case-Control Studies

Max 63

Case-Control Studies

Max 58

Cross-Sectional & Case Series

Max 50

Expert Opinion

Max 5
StrongerWeaker
Randomized Trials
Level 1b
75

75 / 100

Quality score

Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.

Can establish causation

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Key takeaways

Summary

Based on the study abstract and findings.

  1. 1Yes — these changes are meaningful for athletes: bigger muscles, less fat, stronger lifts, and less fatigue mean better training results and recovery.
  2. 2After 8 weeks of taking 3g daily: KleanCREATINE™ users lost 14.45% more body fat, gained 10.46% more muscle, lifted 60% more on chest press (vs 49% with regular creatine), had bigger arms (12.65% vs 6.65%) and thighs (10.36% vs 4.65%), and felt 26.4% less tired during workouts.

Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data

Publication

Journal

Cureus

Year

2026

Authors

Pravin K. Aggarwal, Ramshyam Agarwal

Open Access
Analysis v5

Related Content

Claims (7)

Assertion

In active men aged 18–40 who lift weights, taking 3 grams of KleanCREATINE™ daily for eight weeks increases chest press strength by 60%, which is greater than the 49% increase seen with a standard creatine supplement.

Causal
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Assertion

In active men aged 18–40 who perform resistance training, both micronized creatine monohydrate and a standard creatine monohydrate supplement are safe and well tolerated over eight weeks, with no clinically significant adverse events observed.

Descriptive
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Assertion

Among active men aged 18–40 who perform resistance training, taking 3 grams of micronized creatine monohydrate (KleanCREATINE™) daily for eight weeks leads to a 14.45% larger decrease in body fat percentage and a 10.46% larger increase in skeletal muscle mass than taking a standard creatine monohydrate supplement.

Causal
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Assertion

After taking a 3 gram dose, micronized creatine monohydrate (KleanCREATINE™) reaches higher levels in the blood and peaks one hour sooner than standard creatine monohydrate in active men aged 18–40 who perform resistance training.

Quantitative
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Assertion

Among active men aged 18–40 who lift weights, taking 3 grams of a specific micronized creatine monohydrate supplement daily for eight weeks reduces how hard they feel their workouts are by 26.4%, compared to a 13.46% reduction with a different creatine supplement.

Causal
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Assertion

In active men aged 18–40 who perform resistance training, taking 3 grams of micronized creatine monohydrate (KleanCREATINE™) daily for eight weeks results in a 12.65% increase in arm circumference and a 10.36% increase in thigh circumference, which are larger increases than those seen with a standard creatine monohydrate formulation.

Causal
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