Can a plant oil help soothe stressed-out arthritic joints?
Eucalyptol Ameliorates Neuroendocrine Stress-Aggravated Rheumatoid Arthritis Through Anti-inflammatory, Antioxidant, and Chondroprotective Mechanisms Associated with NF-κB and MAPK Signaling Pathways
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave rats a plant oil called eucalyptol to see if it could calm down their swollen, painful joints caused by stress and an immune system mistake.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 516 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave rats a plant oil called eucalyptol to see if it could calm down their swollen, painful joints caused by stress and an immune system mistake.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 516 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
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Claims (6)
Prolonged psychological stress increases the severity of autoimmune disease activity by maintaining high levels of stress hormones in the body.
In rats with induced arthritis and stress, daily oral eucalyptol at 200 mg/kg for 14 days reduced joint swelling by 62%, increased grip strength by 172%, and restored joint tissue structure compared to stressed rats not given eucalyptol.
In rats with stress-induced rheumatoid arthritis, daily eucalyptol at 200 mg/kg lowered levels of two inflammatory markers (TNF-α and IL-6) and raised levels of an anti-inflammatory marker (IL-10), changing the overall cytokine balance toward reduced inflammation.
In rats with arthritis worsened by stress, a daily dose of 200 mg/kg of eucalyptol lowered malondialdehyde by 55% and doubled superoxide dismutase activity, restoring redox balance in joint tissue.
In rats with arthritis worsened by stress, a daily dose of 200 mg/kg of eucalyptol lowers the levels of specific inflammatory signaling proteins in the blood by 40–50%.