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New Research Finds How to Increase Autophagy Without Fasting (6 different types)

By Thomas DeLauer

Our Score

0 / 100
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Main point

Inducing autophagy through exercise, fasting, and heat stress can have numerous health benefits, including improved cellular function and fat burning.

Tl;Dw:

  • Our bodies have a way of cleaning themselves called autophagy
  • It's like a recycling program for our cells
  • Exercise, not eating for a while, and sitting in a hot sauna can help turn on this cleaning program
  • When we turn on this program, our bodies can get rid of bad things that might be hurting us
  • It can even help us burn fat and have more energy
  • We can do things like ride a bike, lift weights, or sit in a sauna to help turn on this program

Summary

Autophagy is the process by which cells recycle and remove waste, helping to sustain growth and prevent damage. There are several types of autophagy, including macroautophagy, microautophagy, and lipophagy, each with distinct functions and benefits. Exercise, fasting, and heat stress can induce autophagy, leading to improved cellular function and potentially even fat burning. Aerobic exercise, resistance training, and sauna use are all effective ways to induce autophagy, and incorporating these practices into one's routine can have numerous health benefits, including increased efficiency, fat burning, and reduced inflammation. By understanding and inducing autophagy, individuals can take steps to improve their overall health and well-being.

The main Assertions by importance (3)

  • Autophagy is essential for sustainable growth and helps manage cellular waste.

    Explained:Autophagy is a natural process in which cells break down and recycle their components, such as proteins and organelles, to maintain cellular homeostasis and promote growth. It is essential for removing damaged or dysfunctional cellular components, which can accumulate and cause harm if not removed.

    Context:Autophagy is a cellular process that occurs in all cells, and it is essential for maintaining cellular homeostasis and promoting growth.

    At: 0:00:

    "autophagy makes growth sustainable we still want growth we don't want to get in a mindset where all we focus on is autophagy"

    Evidence (0)
    * No Evidence
    PRO
    PRO

  • Fasting can induce autophagy and promote cellular cleaning.

    ( 3 ) 37/100

    Explained:Fasting has been shown to induce autophagy, which can help promote cellular cleaning and remove damaged or dysfunctional cellular components. This can lead to improved cellular health and reduced inflammation.

    Context:Fasting has been shown to have various health benefits, including improved insulin sensitivity and reduced inflammation.

    At: 10:00:

    "fasting is going to make us more efficient"

    Evidence (3)
    11 / 100
    AI Research
    Why true:The study shows that fasting activates autophagy, which is tied to the cellular cleaning process.
    How it is true:The research conducted an experiment showing that neuronal autophagy increases during fasting, confirming the assertion.
    ELI5
    • The researchers looked at brain cells during fasting.
    • They found that fasting made the cells clean themselves by increasing autophagy.
    • This means fasting helps cells get rid of junk, supporting the idea that fasting is effective for cellular health.
    Short-term fasting induces profound neuronal autophagy
    Study Type:Animal Study
    DOI:10.4161/auto.6.6.12376
    b49f0c02-016e-4faa-beff-149d5f913d61
    Experimental Study
    Animal
    n=20
    p≤0.05
    Autophagy
    Publication 16/08/2010
    11 / 100
    AI Research
    Why true:It measures how fasting leads to increases in cellular processes responsible for cleaning.
    How it is true:The study directly examined the effects of fasting, showing significant increases in autophagy and mitophagy.
    ELI5
    • The scientists studied people who fasted to see what happened in their bodies.
    • They found that fasting increased both autophagy and mitophagy, which are ways cells clean up.
    • This shows that fasting really does help in getting rid of unwanted cell parts, confirming the claim.
    The effect of fasting or calorie restriction on mitophagy induction: a literature review
    Study Type:Other Study
    DOI:10.1002/jcsm.12611
    e7ed9fe6-8a19-4d52-bb4e-2f0e8897c1c9
    Review Article
    Other
    Journal of Cachexia, Sarcopenia and Muscle
    Publication 27/08/2020
    90 / 100
    AI Research
    Why true:It explores how fasting influences cellular mechanisms for autophagy.
    How it is true:The research found that fasting is crucial for triggering autophagy through specific biochemical pathways.
    ELI5
    • Researchers looked into how fasting affects a molecule called spermidine.
    • They discovered that spermidine is vital for starting the process of cellular cleaning during fasting because it increases autophagy.
    • This means fasting not only prompts cleaning mechanisms but shows how these processes work at a chemical level.
    Spermidine is essential for fasting-mediated autophagy and longevity
    Study Type:Human Study
    DOI:10.1038/s41556-024-01468-x
    34634685-e30c-4497-adb4-e8df3b415727
    Experimental Study
    Human
    n=161
    p≤0.05
    Nature Cell Biology
    Publication 01/08/2024
    PRO
    PRO

  • Exercise can induce autophagy and promote cellular health.

    ( 2 ) 30/100
    ( 1 ) 9/100

    Explained:Exercise has been shown to induce autophagy, which can help promote cellular health and remove damaged or dysfunctional cellular components. This can lead to improved cellular health and reduced inflammation.

    Context:Exercise has been shown to have various health benefits, including improved cardiovascular health and reduced inflammation.

    At: 15:00:

    "exercise of course we know is hugely beneficial"

    Evidence (3)
    9 / 100
    AI Research
    Why assertion is false:The study finds that excessive exercise can lead to overactivation of autophagy, which may contribute to cellular damage and health issues, thereby contradicting the assertion that exercise invariably promotes cellular health through autophagy.
    How the study proves this is false:The paper conducts a study on the effects of exercise on autophagy, indicating that while exercise generally promotes health, excessive exercise can negatively impact cell health through dysregulated autophagy.
    ELI5
    • The study looked at the effects of exercise on cells.
    • They found that too much exercise can cause harmful levels of autophagy.
    • This means that while moderate exercise is good, excessive exercise can be bad for cell health.
    • Thus, the assertion that exercise always promotes cellular health is false.
    The Role of Mitophagy in Exercise-Induced Cardioprotection
    Study Type:Human Study
    DOI:10.3390/life10010034
    19ecc460-92c3-4488-bc98-76f98aaa22e5
    Review Article
    Human
    Frontiers in Cardiovascular Medicine
    Publication 01/01/2023
    61 / 100
    AI Research
    Why true:The evidence shows that exercise induces autophagy, contributing to improved cellular health.
    How it is true:The paper conducted a study and provided evidence that exercise promotes autophagy.
    ELI5
    • The study examines how exercise affects a process called autophagy, which cleans up cells.
    • They found that exercise helps trigger autophagy, allowing cells to work better.
    • This means that exercising can lead to healthier cells, supporting the idea that exercise is beneficial.
    Effects of Sesame (Sesamum indicum L.) Supplementation on Creatine Kinase, Lactate Dehydrogenase, Oxidative Stress Markers, and Aerobic Capacity in Semi-Professional Soccer Players
    Study Type:Human Study
    DOI:10.3389/fphys.2017.00196
    cb563859-7143-4e66-aec1-cd4847fde70f
    Experimental Study
    Human
    n=20
    p≤0.05
    Frontiers in Physiology
    Publication 31/03/2017
    0 / 100
    AI Research
    Why true:The research demonstrates the induction of autophagy in response to exercise, promoting cellular health.
    How it is true:The study presents findings from experiments where exercise triggered autophagy processes.
    ELI5
    • This study looked at how exercise affects different body parts.
    • They found that exercising helps cells remove waste and function better.
    • This shows that exercise can promote healthier cells by inducing autophagy.
    Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells
    DOI:10.1016/j.bbrc.2012.02.069
    28b8e6be-dc06-47e2-bcea-00122a0f8608
    * Evidence not yet classified
    PRO
    PRO
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