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Powerful Way to Increase Autophagy by 40% Without Fasting (new study) - Biochemist Mike Mutzel

By Thomas DeLauer

Our Score

56 / 100
0 / 100

Main point

Incorporating exercise and fasting into one's lifestyle can improve autophagy, metabolic health, and longevity, with physically fit individuals experiencing greater benefits from fasting.

Tl;Dw:

  • Our bodies have a way of cleaning themselves called autophagy
  • Exercise, especially the kind that makes you breathe hard, can help make autophagy work better
  • When we don't eat for a while, like when we fast, our bodies start to clean themselves more
  • People who exercise a lot and are very fit can get more benefits from fasting because their bodies are already good at cleaning themselves
  • We can get healthier and live longer if we exercise and fast in a way that helps our bodies clean themselves

Summary

A study found that physically fit individuals, measured by their V2 Max, experience greater levels of autophagy when fasting, regardless of the duration of the fast. Autophagy is a cellular recycling process that can help with longevity and cancer prevention. The study showed that individuals with higher V2 Max levels had a 40% increase in autophagy at every time point during a 36-hour fast. Exercise, particularly endurance training, can increase V2 Max and improve metabolic health, allowing individuals to get more benefits from fasting. A hybrid approach that combines strength training and endurance exercise may be the most effective way to improve overall health and increase autophagy. The conclusion is that incorporating exercise, particularly high-intensity interval training, and fasting into one's lifestyle can have numerous health benefits, including improved autophagy, metabolic health, and longevity.

The main Assertions by importance (3)

  • Regular exercise can increase autophagy by up to 40%.

    ( 1 ) 57/100
    ( 1 ) 57/100

    Explained:The text explains that a study found that individuals with higher VO2 max levels, indicating better physical fitness, had greater levels of autophagy when fasting. This suggests that regular exercise can enhance autophagy, which is important for cellular health and longevity.

    Context:The context of this assertion is the discussion of the benefits of exercise and fasting for autophagy and overall health.

    At: 0:42:

    "The more physically fit individuals are, they get greater levels of autophagy when they fast, irrespective of the time of the duration of the fast."

    Evidence (2)
    57 / 100
    From Author
    Why true:The study found that individuals with higher VO2 max levels had greater levels of autophagy when fasting, which directly supports the assertion that regular exercise can increase autophagy.
    How it is true:The study conducted a clinical trial and found a significant correlation between VO2 max and autophagy, providing strong evidence for the assertion.
    ELI5
    • The study tested the claim by measuring autophagy levels in individuals with different VO2 max levels.
    • They found that individuals with higher VO2 max levels had greater levels of autophagy.
    • This means that regular exercise can increase autophagy, which is important for cellular health and longevity.
    Training state and skeletal muscle autophagy in response to 36 h of fasting
    Study Type:Human Study
    DOI:10.1152/japplphysiol.01146.2017
    18186324-f5e5-4156-8cb0-6c9a4459e8e0
    Experimental Study
    Human
    n=13
    p≤0.05
    Journal of Applied Physiology
    Publication 01/11/2018
    57 / 100
    AI Research
    Why assertion is false:The study measured autophagy biomarkers in fit individuals and found they had 40% more autophagy during fasting, thus providing direct evidence.
    How the study proves this is false:The study is a clinical trial that provides empirical data rather than an opinion or review.
    ELI5
    • The study looked at how fit people respond to fasting.
    • It measured something called autophagy, which is like recycling for cells.
    • They found that fit people had 40% more recycling happening when they fasted.
    • This shows that exercise boosts this recycling process.
    Training state and skeletal muscle autophagy in response to 36 h of fasting
    Study Type:Human Study
    DOI:10.1152/japplphysiol.01146.2017
    18186324-f5e5-4156-8cb0-6c9a4459e8e0
    Experimental Study
    Human
    n=13
    p≤0.05
    Journal of Applied Physiology
    Publication 01/11/2018
    PRO
    PRO

  • A higher VO2 max is associated with greater levels of autophagy and improved overall health.

    ( 2 ) 57/100

    Explained:The text explains that a higher VO2 max, which indicates better physical fitness, is associated with greater levels of autophagy and improved overall health.

    Context:The context of this assertion is the discussion of the benefits of exercise for autophagy and overall health.

    At: 8:38:

    "A higher VO2 max is associated with greater levels of autophagy and improved overall health."

    Evidence (2)
    57 / 100
    From Author
    Why true:The study found that individuals with higher VO2 max levels had greater levels of autophagy and improved overall health, which directly supports the assertion.
    How it is true:The study conducted a clinical trial and found a significant correlation between VO2 max and autophagy, providing strong evidence for the assertion.
    ELI5
    • The study tested the claim by measuring VO2 max levels in individuals with different levels of autophagy.
    • They found that individuals with higher VO2 max levels had greater levels of autophagy and improved overall health.
    • This means that a higher VO2 max is a key indicator of the benefits of exercise for autophagy and overall health.
    Training state and skeletal muscle autophagy in response to 36 h of fasting
    Study Type:Human Study
    DOI:10.1152/japplphysiol.01146.2017
    18186324-f5e5-4156-8cb0-6c9a4459e8e0
    Experimental Study
    Human
    n=13
    p≤0.05
    Journal of Applied Physiology
    Publication 01/11/2018
    57 / 100
    AI Research
    Why true:The study measured autophagy initiation proteins across various time points in subjects with different VO2 max levels, and found that higher VO2 max corresponded with elevated autophagy levels.
    How it is true:The study conducted measurements on subjects themselves, finding a 40% increase in autophagy levels correlated with higher VO2 max; this is primary research.
    ELI5
    • The researchers looked at how well trained individuals respond to fasting by measuring autophagy.
    • They compared the levels of autophagy in individuals with different fitness levels (measured by VO2 max).
    • They found that those with higher VO2 max consistently showed greater levels of autophagy during the fasting period.
    • This means that being fitter, indicated by a higher VO2 max, is connected to better cellular cleanup and recovery processes, which supports better overall health.
    Training state and skeletal muscle autophagy in response to 36 h of fasting
    Study Type:Human Study
    DOI:10.1152/japplphysiol.01146.2017
    4a1a8ab9-0e23-47fa-897a-8f57183a5f85
    Experimental Study
    Human
    n=13
    p≤0.05
    Journal of Applied Physiology
    Publication 01/11/2018
    PRO
    PRO

  • Endurance training increases autophagy and improves mitochondrial function.

    Explained:The text explains that endurance training, such as running or cycling, can increase autophagy and improve mitochondrial function, which is important for energy production and overall health.

    Context:The context of this assertion is the discussion of the benefits of different types of exercise for autophagy and overall health.

    At: 18:25:

    "Endurance exercise is a great tool to increase autophagy and improve mitochondrial function."

    Evidence (0)
    * No Evidence
    PRO
    PRO
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