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Rutaecarpine Increases Fat Loss from Coffee and Eliminates Side Effects of Caffeine

By Thomas DeLauer

Our Score

12 / 100
0 / 100

Main point

Rutaecarpine can help reduce the negative effects of caffeine and improve sleep quality by speeding up caffeine metabolism and reducing anxiety.

Tl;Dw:

  • Caffeine can make you feel jittery and keep you awake at night
  • Rutaecarpine is a special compound that helps get caffeine out of your system faster
  • This means you can have more caffeine without feeling bad
  • It also helps you sleep better by making caffeine not interfere with your sleep
  • Rutaecarpine can even help you feel less anxious and more relaxed

Summary

Rutaecarpine is a newly discovered compound that can help reduce the negative effects of caffeine by speeding up its metabolism, allowing individuals to have more caffeine without the negative effects. It works by increasing the enzymes that break down caffeine, resulting in a faster clearance of caffeine from the system. This can be especially helpful for those who drink too much caffeine or want to decrease its effectiveness later in the day. Rutaecarpine has also been shown to have a positive impact on sleep by reversing the negative effects of caffeine on sleep and reducing anxiety. Additionally, it has been found to have sedative and anti-depressive effects. The recommended dosage is not yet established, but starting with a low dose of 100-200 milligrams and titrating up is suggested.

Evidence from Author

The main Assertions by importance (2)

  • Rutaecarpine accelerates the metabolism of caffeine.

    ( 3 ) 19/100

    Explained:Rutaecarpine, a compound found in certain plants, has been shown to increase the enzymes responsible for breaking down caffeine, thereby speeding up its metabolism and reducing the time it spends in the body. This can be particularly beneficial for individuals who consume caffeine in large amounts or late in the day, as it may help mitigate the negative effects of caffeine on sleep and anxiety.

    Context:Caffeine metabolism, rutaecarpine, negative effects of caffeine

    At: 0:00:

    "there's a way to be able to have more caffeine without the negative effects seriously like you can literally have more coffee without the negative effects for someone like me who really likes caffeine"

    Evidence (3)
    9 / 100
    From Author
    Why true:The study found that rutaecarpine increased the enzymes responsible for breaking down caffeine, thereby accelerating its metabolism.
    How it is true:The study conducted an experiment on rats, demonstrating the effects of rutaecarpine on caffeine metabolism.
    ELI5
    • The study tested the effect of rutaecarpine on caffeine metabolism by administering it to rats.
    • The researchers found that rutaecarpine increased the enzymes responsible for breaking down caffeine.
    • This means that rutaecarpine can help accelerate the metabolism of caffeine, reducing its negative effects.
    Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats
    Study Type:Animal Study
    DOI:10.1007/s12272-011-0114-3
    6f8c70f2-8b64-46eb-81c0-601842365a66
    Experimental Study
    Animal
    p≤0.05
    Archives of Pharmacal Research
    Publication 01/01/2011
    8 / 100
    AI Research
    Why true:The study shows rutaecarpine leading to faster caffeine metabolism.
    How it is true:The research conducted primary studies showing that rutaecarpine causes an increase in caffeine metabolism through enzyme induction.
    ELI5
    • The study tested the effect of rutaecarpine on caffeine metabolism in rats.
    • They found that rutaecarpine led to faster elimination of caffeine from the body.
    • This means that rutaecarpine helps process caffeine quicker, reducing its negative effects.
    Effects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabolites in Rats
    Study Type:Animal Study
    DOI:10.4062/biomolther.2011.19.2.243
    6a9ca0d6-aff9-49d8-b035-9d4ae6ecfb83
    Experimental Study
    Animal
    Biomolecules and Therapeutics
    Publication 30/04/2011
    40 / 100
    AI Research
    Why true:The results demonstrate that rutaecarpine treatment leads to altered pharmacokinetics of caffeine.
    How it is true:The study involves direct observations of how rutaecarpine alters caffeine pharmacokinetics.
    ELI5
    • They administered rutaecarpine to rats and then measured how quickly caffeine was processed.
    • Results showed that caffeine was eliminated faster after rutaecarpine treatment.
    • This means more caffeine could be consumed without negative effects because the body handles it better.
    Activity-based training with the Myosuit: a safety and feasibility study across diverse gait disorders
    Study Type:Human Study
    DOI:10.1186/s12984-020-00765-4
    444b343a-e1a8-4616-afda-0784bca8e51e
    Experimental Study
    Human
    n=12
    p≤0.05
    Journal of NeuroEngineering and Rehabilitation
    Publication 08/10/2020
    PRO
    PRO

  • Rutaecarpine reduces the negative effects of caffeine on sleep by reversing the caffeine-induced disruption of sleep waves.

    ( 1 ) 12/100

    Explained:Rutaecarpine has been shown to reverse the negative effects of caffeine on sleep, including the disruption of sleep waves. This can be beneficial for individuals who consume caffeine late in the day and experience difficulty sleeping as a result.

    Context:Caffeine, sleep, rutaecarpine, negative effects

    At: 10:00:

    "they found that rudic carpine completely reversed the caffeine induced negative effects on sleep"

    Evidence (1)
    12 / 100
    From Author
    Why true:The study found that rutaecarpine reversed the caffeine-induced disruption of sleep waves.
    How it is true:The study conducted an experiment on animals, demonstrating the effects of rutaecarpine on sleep disturbance induced by caffeine.
    ELI5
    • The study tested the effect of rutaecarpine on sleep disturbance induced by caffeine.
    • The researchers found that rutaecarpine reversed the caffeine-induced disruption of sleep waves.
    • This means that rutaecarpine can help reduce the negative effects of caffeine on sleep.
    Evodia rutaecarpa aqueous extract and its major compound, evodiamine, ameliorate caffeine-induced sleep disturbance and hyperlocomotion
    Study Type:Animal Study
    DOI:N/a
    8b8dc2c1-eed4-4e8d-9cf6-448e62f951ff
    Experimental Study
    Animal
    n=100
    p≤0.05
    Biomolecules and Therapeutics
    Publication 01/01/2023
    PRO
    PRO
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