25 gene variants across 4 locations had different effects on body fat in men versus women.

Scientific Claim

Twenty-five single nucleotide polymorphisms across four loci showed significant sex-specific interaction effects on body fat percentage in a combined analysis of 312,274 UK Biobank participants.

Original Statement

“Only 25 SNPs in 4 loci reached the GWS threshold: rs754823863, rs16885587, rs5030937 and rs55745760 (Figure 3C, Table S9).”

From study:Beyond apples and pears: sex-specific genetics of body fat percentage

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim accurately reports the number of SNPs with sex-specific interactions, using appropriate association language for observational data.

Evidence from Studies

Supporting (1)

Beyond apples and pears: sex-specific genetics of body fat percentage

Cross-Sectional Study

Human

2023

Contradicting (0)

No contradicting evidence found

Source Study

Beyond apples and pears: sex-specific genetics of body fat percentage

Score: 49

DOI: 10.3389/fendo.2023.1274791

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