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Strong Support
causal
Analysis v1
History

A drug called AMG 145, when given every two weeks, cuts bad cholesterol by about three-quarters in people with high cholesterol who are already on strong meds or have a genetic form of the condition...

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Pro
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Against

Evidence from Studies

Supporting (1)

63

Community contributions welcome

63

Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins.

Randomized Controlled Trial
Human
2012 Nov 6

Contradicting (0)

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No contradicting evidence found

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Source Study

Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins.

Score: 63
DOI: 10.1016/j.jacc.2012.08.986

Similar Assertions

A shot called AMG 145, given once a month, can cut bad cholesterol by more than 60% in people already on cholesterol meds — and it stays effective the whole month.

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94%

A drug called AMG 145, when given as a weekly shot at 35 mg or more, can cut bad cholesterol by up to 81% in people already on cholesterol meds, and the effect lasts through the week—so it might work well even if given every other week.

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91%

A drug called AMG 145 seems to lower a harmful type of cholesterol called Lp(a) by up to half in people already taking cholesterol meds, and it might work in a new way doctors haven’t seen before.

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89%

A shot of a drug called AMG 145 can quickly lower bad cholesterol—by up to 64% in just a few days—especially when given at higher doses, and it works by targeting a specific protein in the body.

63
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83%

A drug called AMG 145 can lower a harmful blood protein linked to heart disease by up to 59% in people with high cholesterol who are already taking statins, and it seems to do more than just lower bad cholesterol.

63
0
80%