A medicine that helps lower bad cholesterol
Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
AMG 145 lowered lipoprotein(a) [Lp(a)] by 27% to 50%, a type of cholesterol that most drugs don’t touch.
Lp(a) is genetically driven and resistant to statins—doctors have long said 'there’s nothing we can do' about it. This suggests PCSK9 inhibitors might change that.
Practical Takeaways
If you're on statins but still have high cholesterol, ask your doctor about PCSK9 inhibitors like this one.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
AMG 145 lowered lipoprotein(a) [Lp(a)] by 27% to 50%, a type of cholesterol that most drugs don’t touch.
Lp(a) is genetically driven and resistant to statins—doctors have long said 'there’s nothing we can do' about it. This suggests PCSK9 inhibitors might change that.
Practical Takeaways
If you're on statins but still have high cholesterol, ask your doctor about PCSK9 inhibitors like this one.
Publication
Journal
Journal of the American College of Cardiology
Year
2012
Authors
C. Dias, A. Shaywitz, S. Wasserman, Brian Smith, Bing Gao, Dina Stolman, C. Crispino, K. Smirnakis, M. Emery, A. Colbert, J. Gibbs, M. Retter, Blaire P. Cooke, Stephen Uy, M. Matson, E. Stein
Related Content
Claims (8)
Adding PCSK9 drugs to cholesterol-lowering statins can slash bad cholesterol by as much as 81% in people with high cholesterol.
A drug called AMG 145, when given every two weeks, cuts bad cholesterol by about three-quarters in people with high cholesterol who are already on strong meds or have a genetic form of the condition — even when their options are limited.
A drug called AMG 145 can lower a harmful blood protein linked to heart disease by up to 59% in people with high cholesterol who are already taking statins, and it seems to do more than just lower bad cholesterol.
A shot called AMG 145, given once a month, can cut bad cholesterol by more than 60% in people already on cholesterol meds — and it stays effective the whole month.
A shot of a drug called AMG 145 can quickly lower bad cholesterol—by up to 64% in just a few days—especially when given at higher doses, and it works by targeting a specific protein in the body.