A drug called AMG 145 can lower a harmful blood protein linked to heart disease by up to 59% in people with high cholesterol who are already taking statins, and it seems to do more than just lower bad cholesterol.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins.

Randomized Controlled Trial

Human

2012 Nov 6

The study tested the same drug (AMG 145) in the same group of people and found it greatly lowered bad cholesterol. While it didn’t directly measure ApoB, the results still support the idea that the drug reduces harmful particles in the blood.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins.

Score: 63

DOI: 10.1016/j.jacc.2012.08.986

Similar Assertions

A drug called AMG 145 seems to lower a harmful type of cholesterol called Lp(a) by up to half in people already taking cholesterol meds, and it might work in a new way doctors haven’t seen before.

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84%

A shot of a drug called AMG 145 can quickly lower bad cholesterol—by up to 64% in just a few days—especially when given at higher doses, and it works by targeting a specific protein in the body.

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80%

A drug called AMG 145, when given every two weeks, cuts bad cholesterol by about three-quarters in people with high cholesterol who are already on strong meds or have a genetic form of the condition — even when their options are limited.

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80%

A shot called AMG 145, given once a month, can cut bad cholesterol by more than 60% in people already on cholesterol meds — and it stays effective the whole month.

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77%

A drug called AMG 145, when given as a weekly shot at 35 mg or more, can cut bad cholesterol by up to 81% in people already on cholesterol meds, and the effect lasts through the week—so it might work well even if given every other week.

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