Back to The 60-Year Cholesterol War Is Finally Over
Strong Support
mechanistic
Analysis v1
History

Blocking a protein called PCSK9 with certain drugs helps your body remove bad cholesterol from your blood more effectively.

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Against

Evidence from Studies

Supporting (5)

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63

Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins.

Randomized Controlled Trial
Human
2012 Nov 6
1

PCSK9 Inhibition: From Current Advances to Evolving Future

Narrative Review
2022 Sep 23
1

PCSK9 Inhibition: Insights From Clinical Trials and Future Prospects

Narrative Review
In Vitro
2020
1

The role of PCSK9 in heart failure and other cardiovascular diseases—mechanisms of action beyond its effect on LDL cholesterol

Narrative Review
2024 Sep
1

Therapeutic PCSK9 targeting: Inside versus outside the hepatocyte?

Narrative Review
2025 Apr

Contradicting (0)

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No contradicting evidence found

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Similar Assertions

These special lab-made antibodies grab onto a protein in your blood that messes with cholesterol cleanup, so your body can get rid of bad cholesterol better and lower your chances of heart problems.

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88%

A type of medicine (like evolocumab or alirocumab) blocks a protein in your body called PCSK9, which helps your liver remove bad cholesterol from your blood—cutting it by about half.

1
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87%

A protein called PCSK9 causes the liver to break down fewer 'bad' cholesterol carriers, which means more of it stays in your blood.

1
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80%

Taking a cholesterol drug called evolocumab to get really low LDL levels doesn’t seem to cause serious side effects like memory problems, diabetes, cataracts, or brain bleeds over 3 years, according to a major study.

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77%

Taking a drug called evolocumab can lower the chance of having a first major heart problem by 25% in people at high risk who’ve never had a heart attack or stroke before.

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76%

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