How do different cholesterol medicines work?
Therapeutic PCSK9 targeting: Inside versus outside the hepatocyte?
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some medicines grab bad cholesterol helpers in the blood, while others stop the body from making them in the liver. Both help lower bad cholesterol even more when used with regular pills.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 51 / 5
Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some medicines grab bad cholesterol helpers in the blood, while others stop the body from making them in the liver. Both help lower bad cholesterol even more when used with regular pills.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 51 / 5
Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Publication
Authors
Corsini A, Ginsberg HN, Chapman MJ
Related Content
Claims (5)
Blocking a protein called PCSK9 with certain drugs helps your body remove bad cholesterol from your blood more effectively.
Inclisiran is a type of medicine that helps lower bad cholesterol by turning down a protein in the liver. It works longer than some other cholesterol drugs, so you don’t need to take it as often.
One type of cholesterol drug makes the body produce more of a protein called PCSK9, while another type actually reduces it — so they work in opposite ways even though they target the same thing.
Two newer cholesterol drugs, when added to the strongest statins, can cut bad cholesterol by another half — helping high-risk patients get their levels down to what doctors recommend.
These special lab-made antibodies grab onto a protein in your blood that messes with cholesterol cleanup, so your body can get rid of bad cholesterol better and lower your chances of heart problems.