Inclisiran is a type of medicine that helps lower bad cholesterol by turning down a protein in the liver. It works longer than some other cholesterol drugs, so you don’t need to take it as often.

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Evidence from Studies

Supporting (1)

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Therapeutic PCSK9 targeting: Inside versus outside the hepatocyte?

Narrative Review

2025 Apr

The study shows that inclisiran works by reducing the production of a protein called PCSK9 in the liver, which lowers bad cholesterol by about half, just like the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Therapeutic PCSK9 targeting: Inside versus outside the hepatocyte?

Score: 1

DOI: 10.1016/j.pharmthera.2025.108812

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Two newer cholesterol drugs, when added to the strongest statins, can cut bad cholesterol by another half — helping high-risk patients get their levels down to what doctors recommend.

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One type of cholesterol drug makes the body produce more of a protein called PCSK9, while another type actually reduces it — so they work in opposite ways even though they target the same thing.

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A shot called inclisiran can cut bad cholesterol by more than half in people at high risk for heart problems, and it works with just two doses a year.

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