mechanistic
A brain pathway activated by the fat hormone leptin turns up the body’s ‘fight or flight’ system and raises blood pressure in obesity—even when insulin is high—so this brain signal may be more important than insulin for causing high blood pressure.
Evidence from Studies
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Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.