A common antihistamine called meclizine was given to mice, and it helped them live about 8% longer on average. The mice started getting the drug when they were middle-aged (equivalent to about 40 in human years), and scientists confirmed this result was statistically meaningful.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Cohort Study

Animal

2024 Feb

This study directly confirms the claim - it tested the exact same drug (meclizine) in the exact same type of mice (male UM-HET3) starting at the same age (12 months) and found the exact same result (8% lifespan extension with p=0.03).

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Score: 13

DOI: 10.1007/s11357-023-01011-0

Similar Assertions

Male mice have more meclizine in their blood than female mice, and this might be why the males live longer when given this drug.

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