Male mice have more meclizine in their blood than female mice, and this might be why the males live longer when given this drug.

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Pro

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Against

Evidence from Studies

Supporting (0)

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No supporting evidence found

Contradicting (1)

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Community contributions welcome

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Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Cohort Study

Animal

2024 Feb

The study shows meclizine helps male mice live longer, but it doesn't measure blood levels to prove males have more drug in their blood than females. The claim about blood levels is an unproven explanation for why only males benefited.

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Score: 13

DOI: 10.1007/s11357-023-01011-0

Similar Assertions

Two supplements—astaxanthin and meclizine—helped male mice live longer, but female mice didn't get the same benefit when given the same amounts.

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80%

A common antihistamine called meclizine was given to mice, and it helped them live about 8% longer on average. The mice started getting the drug when they were middle-aged (equivalent to about 40 in human years), and scientists confirmed this result was statistically meaningful.

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74%