Two supplements—astaxanthin and meclizine—helped male mice live longer, but female mice didn't get the same benefit when given the same amounts.

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Pro

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Against

Evidence from Studies

Supporting (1)

13

Community contributions welcome

13

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Cohort Study

Animal

2024 Feb

The study gave astaxanthin and meclizine to mice and found that both drugs extended the lifespan of male mice but did NOT significantly extend the lifespan of female mice - exactly matching what the claim says.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

Score: 13

DOI: 10.1007/s11357-023-01011-0

Similar Assertions

Scientists gave a red pigment called astaxanthin (found in salmon and shrimp) to older mice and found they lived about 12% longer than mice that didn't get it - that's like a person living an extra 8-10 years.

13

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83%

Male mice have more meclizine in their blood than female mice, and this might be why the males live longer when given this drug.

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13

80%

Scientists gave mice or other lab animals food with three different supplements, but accidentally gave much smaller amounts than they planned. Even with less supplement, two of them (astaxanthin and meclizine) still made the animals live longer.

13

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78%

A red pigment found in shrimp and salmon (astaxanthin) helped male mice live 12% longer when given to middle-aged mice at a high dose, which was the biggest lifespan boost seen in a major government testing program in over a decade.

13

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76%