A shot called inclisiran can cut bad cholesterol by more than half in people at high risk for heart problems, and it works with just two doses a year.

Pro

Against

Evidence from Studies

Supporting (1)

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Proprotein convertase subtilisn/kexin type 9 inhibitors and small interfering RNA therapy for cardiovascular risk reduction: A systematic review and meta-analysis

Systematic Review With Meta-Analysis

Human

2023

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Proprotein convertase subtilisn/kexin type 9 inhibitors and small interfering RNA therapy for cardiovascular risk reduction: A systematic review and meta-analysis

Score: 59

DOI: 10.1371/journal.pone.0295359

Similar Assertions

Inclisiran is a type of medicine that helps lower bad cholesterol by turning down a protein in the liver. It works longer than some other cholesterol drugs, so you don’t need to take it as often.

71%

Two newer cholesterol drugs, when added to the strongest statins, can cut bad cholesterol by another half — helping high-risk patients get their levels down to what doctors recommend.

71%