Heart medicine that lowers bad cholesterol
Proprotein convertase subtilisn/kexin type 9 inhibitors and small interfering RNA therapy for cardiovascular risk reduction: A systematic review and meta-analysis
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some medicines can help lower bad cholesterol and prevent heart problems in people who are already at high risk.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 559 / 100
Evidence Score
The highest quality evidence. These studies systematically search, appraise, and synthesize results from multiple individual studies, providing the most reliable summary of current knowledge.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some medicines can help lower bad cholesterol and prevent heart problems in people who are already at high risk.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 559 / 100
Evidence Score
The highest quality evidence. These studies systematically search, appraise, and synthesize results from multiple individual studies, providing the most reliable summary of current knowledge.
Publication
Authors
Imran TF, Khan AA, Has P, Jacobson A, Bogin S, Khalid M, Khan A, Kim S, Erqou S, Choudhary G, Aspry K, Wu WC
Related Content
Claims (7)
Adding a drug called evolocumab to cholesterol-lowering statins can lower the chances of serious heart problems by 20% in people who already have heart disease.
Adding a drug called evolocumab to cholesterol-lowering statins can lower the chances of serious heart problems by 20% in people who already have heart disease.
A drug called evolocumab, when given every two weeks, cuts bad cholesterol by more than 60% in people at high risk for heart problems — and that result has shown up consistently in several major studies.
A drug called alirocumab, given as a 75mg shot every couple of weeks, lowered bad cholesterol by almost half in people at high risk for heart problems over six months — a bit less than another similar drug, evolocumab.
A drug called alirocumab may help prevent serious heart problems and even lower the chance of dying from heart disease in people at high risk — but we’re still not totally sure about the life-extending effects because the data is limited.