Analysis Version
v1
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causal
Analysis v1
Strong Support

Adding a drug called evolocumab to cholesterol-lowering statins can lower the chances of serious heart problems by 20% in people who already have heart disease.

79
Pro
0
Against

Evidence from Studies

Supporting (3)

79

Community contributions welcome

74

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

Randomized Controlled Trial
Human
2017 May 4

The study shows that adding evolocumab to statins cuts the risk of heart attacks, strokes, and heart-related deaths by 20%, just like the claim says.

59

Proprotein convertase subtilisn/kexin type 9 inhibitors and small interfering RNA therapy for cardiovascular risk reduction: A systematic review and meta-analysis

Systematic Review With Meta-Analysis
Human
2023

The study found that adding evolocumab to statins lowers the risk of serious heart problems, which supports the general idea in the claim, though the benefit was slightly less than 20%.

48

Efficacy of lipid lowering therapy beyond statins to prevent cardiovascular events

Systematic Review With Meta-Analysis
Human

The study looked at adding drugs like evolocumab to statins and found they lower heart problem risks by about 19%, which is almost exactly what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Similar Assertions

For people with serious heart disease who are already taking cholesterol-lowering pills, adding one of two special drugs (evolocumab or alirocumab) can lower their chances of having a major heart problem—like a heart attack—by about 15% over a few years.

1
0
92%

For people with heart disease who are already taking cholesterol-lowering statins but still have high LDL, adding a drug called evolocumab can lower their chances of having a heart attack, stroke, or other serious heart problems by about 15% over two years.

74
0
92%

Even if your cholesterol is already pretty low thanks to statins, adding a drug called evolocumab can still help protect your heart and blood vessels.

74
0
91%

For people with heart disease who are on cholesterol-lowering drugs, adding a drug called evolocumab doesn’t raise their risk of serious side effects like diabetes or memory problems — the only real downside is a slightly higher chance of soreness at the injection site.

74
0
90%

For people with diabetes who are at high heart risk but don’t yet have serious artery disease, adding a drug called evolocumab to their cholesterol medicine (statin) cuts their chance of having a first heart attack, stroke, or heart-related death by about a third over nearly 5 years.

55
0
89%

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