A larger dose of regular whey protein activated a key muscle-building pathway more than hydrolyzed whey protein or no protein in rats.
Scientific Claim
In rats, intact whey protein at 2.0 g/kg body weight was associated with higher phosphorylation of S6K1 at Thr389 compared to the control group 60 minutes post-exercise, whereas whey protein hydrolysate at the same dose was not.
Original Statement
“At a dose of 2.0 g/kg BW, the phosphorylated 4E-BP1 levels in both groups and the phosphorylated S6K1 levels only in the WPC group were significantly higher than in the control group (p < 0.05).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design supports association claims. The phrasing correctly uses 'associated' and specifies the comparison to control.
Evidence from Studies
Supporting (1)
Effects of whey protein hydrolysate ingestion on post-exercise muscle protein synthesis compared with intact whey protein in rats