A moderate amount of nicotine with caffeine doesn’t make people feel sick and still helps reduce hunger, making it a good balance.
Scientific Claim
A combination of 1 mg nicotine and caffeine appears to be well tolerated in healthy young men of normal weight, suggesting a favorable balance between efficacy and side effects.
Original Statement
“The combinations of 1-mg of nicotine with caffeine seem to be well tolerated.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
probability
Can suggest probability/likelihood
Assessment Explanation
The term 'seem to be' is appropriately cautious and matches the abstract’s language. The design supports the observation, but small sample limits confidence. 'May be' strengthens appropriateness.
More Accurate Statement
“A combination of 1 mg nicotine and caffeine may be well tolerated in healthy young men of normal weight.”
Evidence from Studies
Supporting (1)
The appetite‐suppressant effect of nicotine is enhanced by caffeine *
The study found that a small amount of nicotine (1 mg) with caffeine worked well to reduce hunger without making people too sick, especially compared to higher doses that caused nausea in a few people.