A specific protein called DGUOK keeps the energy-producing parts of skin cells working properly. If this protein is missing, the cells' energy factories get damaged and start to swell, which messes...

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Evidence from Studies

Supporting (1)

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Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying

Cohort Study

Animal

2025 Jun 16

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No contradicting evidence found

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Source Study

Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying

Score: 13

DOI: 10.1186/s13619-025-00242-0

Similar Assertions

In mouse skin cells that aren't dividing, a protein called DGUOK helps keep important energy-related genes working properly. If DGUOK is removed, those genes slow down, and the energy factories in cells (mitochondria) swell and get damaged.

91%

Mice that are missing a certain gene have weaker energy production in their skin cells because their mitochondrial genes aren't working as well, especially as their fur starts growing again later in life.

78%