A special iridium compound can make NMR signals much stronger for certain molecules like pyridine by using hydrogen gas, making it easier to detect these molecules in scientific tests.
Scientific Claim
The iridium complex [IrCl(COE)2]2 reacts with pyridine and hydrogen to form IrCl(H)2(COE)(py)2, which can hyperpolarize pyridine and related compounds via SABRE, enhancing NMR signal intensity by over 500-fold under optimal conditions.
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study describes an observed association between the iridium complex and hyperpolarization effects, but does not establish causation. The language 'efficiently achieves' is appropriate for an association claim in this context.
More Accurate Statement
“The iridium complex [IrCl(COE)2]2 reacts with pyridine and hydrogen to form IrCl(H)2(COE)(py)2, which is associated with hyperpolarization of pyridine and related compounds via SABRE, enhancing NMR signal intensity by over 500-fold under optimal conditions.”
Source Excerpt
“When this reaction is studied with parahydrogen, 1 efficiently achieves hyperpolarization of free py (and nicotinamide, nicotine, 5-aminopyrimidine, and 3,5-lutudine) via signal amplification by reversible exchange (SABRE) and hence reflects a simple and readily available precatayst for this process.”
Evidence from Studies
Supporting Evidence (1)
The study describes the formation of IrCl(H)2(COE)(py)2 from [IrCl(COE)2]2 with pyridine and H2, and demonstrates hyperpolarization of pyridine and related compounds using SABRE. The source excerpt directly states this process occurs and provides examples of compounds that are hyperpolarized.