Supercharged NMR magnet for seeing molecules better
Iridium Cyclooctene Complex That Forms a Hyperpolarization Transfer Catalyst before Converting to a Binuclear C–H Bond Activation Product Responsible for Hydrogen Isotope Exchange
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
The binuclear complex is inactive for SABRE but can still transfer magnetization when mixed with the active catalyst
Most researchers would expect inactive catalysts to be useless, but this one actually helps the active catalyst work better by transferring polarization to pyridine molecules.
Practical Takeaways
Use this iridium complex for hyperpolarization in lab settings where air stability and ease of preparation are important
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
The binuclear complex is inactive for SABRE but can still transfer magnetization when mixed with the active catalyst
Most researchers would expect inactive catalysts to be useless, but this one actually helps the active catalyst work better by transferring polarization to pyridine molecules.
Practical Takeaways
Use this iridium complex for hyperpolarization in lab settings where air stability and ease of preparation are important
Publication
Journal
Inorganic Chemistry
Year
2016
Authors
Wissam Iali, G. Green, S. Hart, A. Whitwood, S. Duckett
Related Content
Claims (10)
A special iridium compound can make NMR signals much stronger for certain molecules like pyridine by using hydrogen gas, making it easier to detect these molecules in scientific tests.
The iridium compound loses a pyridine molecule to form a simpler structure that helps transfer polarization during the SABRE process.
The iridium compound has parts that move around quickly at room temperature, with pyridine molecules leaving at about 8 times per second and hydrogen atoms swapping positions about 3.6 times per second.
When this iridium compound is used with special hydrogen gas, it can make NMR signals for pyridine much stronger—over 200 times stronger in some cases.
Over time, the iridium compound changes into a different structure that can swap hydrogen atoms in molecules, which is useful for making labeled compounds for medical imaging.