Over time, the iridium compound changes into a different structure that can swap hydrogen atoms in molecules, which is useful for making labeled compounds for medical imaging.
Scientific Claim
The iridium complex IrCl(H)2(COE)(py)2 converts to a binuclear complex (Cl)(H)(py)(μ-Cl)(μ-H)(κ-μ-NC5H4)Ir(H)(py)2 over 48 hours at 298 K, which is active in hydrogen isotope exchange processes.
Original Statement
“When the sample is left at 298 K for 24 h, three new hydride signals appear in the corresponding 1H NMR spectra at δ −24.72, −25.9, and −28.95 for (Cl)(H)(py)(μ-Cl)(μ-H)(κ-μ-NC5H4)Ir(H)(py)2 (4). [...] 4 therefore facilitates py CH/CD exchange through transfer from D2/H2.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study describes an observed association between the complex and its conversion to a binuclear species with catalytic activity. The language 'converts to' and 'is active in' appropriately describes the observed chemical transformation and activity.
More Accurate Statement
“The iridium complex IrCl(H)2(COE)(py)2 is associated with conversion to a binuclear complex (Cl)(H)(py)(μ-Cl)(μ-H)(κ-μ-NC5H4)Ir(H)(py)2 over 48 hours at 298 K, which is associated with hydrogen isotope exchange processes.”