A specific red light treatment made cartilage cells in a dish produce less of a protein that's typically associated with damaged or healing cartilage
Scientific Claim
Near-infrared light at 850 nm with 4 mW/cm² power density, pulsed mode, applied every other day for 120 seconds, significantly reduced collagen type I expression in cultured human chondrocytes from a 46-year-old female donor
Original Statement
“COL I expression was significantly reduced after 4 mW/cm² at 850 nm (pulsed, every other day, p = 0.003), but remained unaffected in chondrocytes exposed with other PBM protocols”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The study directly measured collagen type I expression with statistical significance for this specific parameter, so 'significantly reduced' is appropriate.
Evidence from Studies
Supporting (1)
Near-infrared photobiomodulation stimulates viability and cartilage matrix synthesis in human chondrocytes