A strong combo of nicotine and caffeine made some people feel sick, but even when those people were removed from the data, the appetite-suppressing effect still held up.
Scientific Claim
The combination of 2 mg nicotine and 100 mg caffeine caused nausea in four non-smokers, but the appetite-suppressing effects persisted even after excluding these individuals.
Original Statement
“The 2-mg dose of nicotine in combination with the 100-mg dose of caffeine caused nausea in four of the non-smokers. However, the effects of nicotine and the caffeine × nicotine × time interaction persisted after the exclusion of these subjects.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
probability
Can suggest probability/likelihood
Assessment Explanation
The claim is descriptive and directly quoted. While the design supports the observation, the small n limits generalizability. 'Caused' is acceptable for this specific observation but should be framed as a probable outcome.
More Accurate Statement
“The combination of 2 mg nicotine and 100 mg caffeine may cause nausea in some non-smokers, but the appetite-suppressing effects of nicotine may still persist after excluding those individuals.”
Evidence from Studies
Supporting (1)
The appetite‐suppressant effect of nicotine is enhanced by caffeine *
The study found that mixing nicotine and caffeine made some people feel sick, but even after removing those people, the combo still made everyone feel less hungry — so the hunger-suppressing effect works even if it causes nausea in a few.