In a type of lab mouse, drinking water with a little vinegar-like acid for two months seems to turn down liver genes that make sugar and fat, possibly by flipping a metabolic switch called AMPK.

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Evidence from Studies

Supporting (1)

9

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9

Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice.

Cross-Sectional Study

Animal

2006 Jun 2

The study shows that giving acetic acid in drinking water to diabetic mice for 8 weeks lowered blood sugar and reduced the activity of liver genes that make sugar and fat, which matches the claim.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice.

Score: 9

DOI: 10.1016/J.BBRC.2006.03.176

Similar Assertions

Eating acetic acid—like what's in vinegar—might help improve metabolism in mice by turning down certain genes in the liver that make sugar and fat.

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Acetic acid might help lower blood sugar in diabetic mice by turning on a key energy-sensing protein in the liver, based on lab tests and gene activity clues.

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Mice with a condition like type 2 diabetes had lower blood sugar after drinking water with a little vinegar (acetic acid) for two months. This suggests vinegar might help control blood sugar in diabetes.

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Mice with type 2 diabetes that drank water with a little vinegar-like acid every day for 8 weeks had lower blood sugar levels than mice that didn’t — suggesting this acid might help manage blood sugar.

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Acetate turns up fat-burning genes in liver cells, but only when a specific switch called AMPK is working — if we turn off that switch, the effect goes away.

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