Eating acetic acid—like what's in vinegar—might help improve metabolism in mice by turning down certain genes in the liver that make sugar and fat.

9

Pro

0

Against

Evidence from Studies

Supporting (1)

9

Community contributions welcome

9

Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice.

Cross-Sectional Study

Animal

2006 Jun 2

The study gave acetic acid to diabetic mice and found it lowered blood sugar and reduced activity of genes involved in sugar and fat production in the liver, likely by turning on a key energy sensor called AMPK.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice.

Score: 9

DOI: 10.1016/j.bbrc.2006.03.176

Similar Assertions

In a type of lab mouse, drinking water with a little vinegar-like acid for two months seems to turn down liver genes that make sugar and fat, possibly by flipping a metabolic switch called AMPK.

9

0

94%

Acetic acid might help lower blood sugar in diabetic mice by turning on a key energy-sensing protein in the liver, based on lab tests and gene activity clues.

9

0

81%

Acetic acid helps liver cells burn fat and stop making too much fat, but only if a key switch in the cell called AMPKα is turned on. If that switch is blocked, acetic acid doesn’t work anymore.

6

0

79%

In rat liver cells, a substance related to vinegar (sodium acetate) turns on a key energy sensor and lowers the activity of genes involved in sugar and fat production, which might explain how vinegar helps with metabolism.

9

0

78%

Acetic acid turns on a key energy sensor in liver cells, which tells the body to start using stored energy.

16

0

78%