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Taking a drug that turns on the glucagon receptor for a long time might affect how the body manages energy and fat, but scientists aren't totally sure how it works yet.

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Shared mechanistic pathways of glucagon signalling: Unlocking its potential for treating obesity, metabolic dysfunction‐associated steatotic liver disease, and other cardio‐kidney‐metabolic conditions

Narrative Review
Animal
2025 Dec

The study looks at drugs that turn on the glucagon receptor in humans and finds they help with weight and liver fat, which matches the idea that this receptor affects energy and fat. But scientists still don’t fully understand how it works.

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Source Study

Shared mechanistic pathways of glucagon signalling: Unlocking its potential for treating obesity, metabolic dysfunction‐associated steatotic liver disease, and other cardio‐kidney‐metabolic conditions

Score: 1
DOI: 10.1111/dom.70148

Similar Assertions

Blocking the glucagon signal in people with type 2 diabetes might cause weight gain, more fat in the liver, and higher blood fat levels — suggesting this hormone helps control how the body uses energy and fat.

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Blocking the hormone glucagon with drugs might actually make things worse for people — causing weight gain, higher blood pressure, and more liver fat.

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Glucagon might help people eat less and lose weight on its own, even if it's not affecting blood sugar — but scientists used to ignore this idea because of old beliefs about how metabolism works.

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Even though glucagon was once thought to be bad for you because it raises blood sugar and stresses the heart, turning it on purpose — especially with other hormones — might actually help your metabolism.

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Turning on two specific body switches—one for glucagon and one for GLP-1—helps burn more energy without raising blood sugar, because one speeds up metabolism and the other keeps blood sugar in check.

3
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