For people with hardened arteries who are on cholesterol-lowering drugs, adding a drug called evolocumab doesn’t seem to raise their risk of bleeding in the brain.

74

Pro

0

Against

Evidence from Studies

Supporting (1)

74

Community contributions welcome

74

Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis

Randomized Controlled Trial

Human

2020 May

The study looked at whether a drug called evolocumab causes more brain bleeds in patients already on statins, and found no increased risk compared to placebo.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis

Score: 74

DOI: 10.1161/STROKEAHA.119.027759

Similar Assertions

For people with clogged arteries who are already on cholesterol drugs, adding a medicine called evolocumab helps lower their risk of heart problems — and it works pretty well even for those who've had a stroke before, though the benefit might be a bit smaller for them.

74

0

88%

For people with heart disease who are already taking cholesterol-lowering statins but still have high LDL, adding a drug called evolocumab can lower their chances of having a heart attack, stroke, or other serious heart problems by about 15% over two years.

74

0

82%

For people with clogged arteries who are already taking cholesterol drugs, adding a medicine called evolocumab can help lower their chance of having a stroke.

74

0

81%

Adding a drug called evolocumab to cholesterol-lowering statins can lower the chances of serious heart problems by 20% in people who already have heart disease.

79

0

81%

For people with heart disease who are on cholesterol-lowering drugs, adding a drug called evolocumab doesn’t raise their risk of serious side effects like diabetes or memory problems — the only real downside is a slightly higher chance of soreness at the injection site.

74

0

81%