Does a cholesterol drug help prevent strokes?
Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A drug called evolocumab was tested in people with hardening of the arteries who were already taking statins. It was compared to a fake treatment to see if it helped prevent strokes.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 574 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A drug called evolocumab was tested in people with hardening of the arteries who were already taking statins. It was compared to a fake treatment to see if it helped prevent strokes.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 574 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Giugliano RP, Pedersen TR, Saver JL, Sever PS, Keech AC, Bohula EA, Murphy SA, Wasserman SM, Honarpour N, Wang H, Lira Pineda A, Sabatine MS, FOURIER Investigators
Related Content
Claims (4)
Taking a drug called evolocumab can lower the chance of having a first major heart problem by 25% in people at high risk who’ve never had a heart attack or stroke before.
For people with clogged arteries who are already taking cholesterol drugs, adding a medicine called evolocumab can help lower their chance of having a stroke.
For people with hardened arteries who are on cholesterol-lowering drugs, adding a drug called evolocumab doesn’t seem to raise their risk of bleeding in the brain.
For people with clogged arteries who are already on cholesterol drugs, adding a medicine called evolocumab helps lower their risk of heart problems — and it works pretty well even for those who've had a stroke before, though the benefit might be a bit smaller for them.